Indian origin scientists discover gene related to sleep patterns Mihika Basu

SCIENTISTS have discovered a gene that is responsible for your sleep patterns. So if you find your sleep cycle disrupted after a jet lag or a graveyard shift at work, it's because Lhx1, the body's timekeeper of sorts, is doing its job.

According to the scientists, both of Indian origin, the discovery of the gene is relevant for modern society where our sleep-wake cycles are disrupted by the schedules we choose to keep. They say the discovery can help in finding treatments for sleep problems, enabling shift-workers or jet-lagged travellers to adjust to time differences.

“We found a gene called Lhx1 that controls how individual clock neurons talk to each other. Such cross-talk helps consolidate activity and sleep to the right time of the day and prevents the sleep time from wandering when the light or dark cycle changes. The study shows that weakening the cross-talk among clock cells can be an effective method to change sleep- or activity-time, which is particularly useful for people who work between day and night shifts, so that they can adjust their sleep-time easily when their work-shift changes. Nearly 10-15 per cent of the workforce in most countries are shift-workers. When they change from night to day shift or when they try to be 'day active' during the weekend, it is very difficult for them to readjust their sleep time. Consequently, they get less sleep, have reduced productivity and, in the long run, are predisposed to many chronic diseases. Finding a treatment to readjust sleeping time will hugely benefit them," said Dr Satchidananda Panda, associate professor at the Salk Institute, in an email interview.

Dr Shubhroz Gill, researcher at Salk Institute and co-first author of the paper, which has been published in the journal eLife, further explained that humans have internal biological clocks that generate 24-hour rhythms for sleep, waking hours and to maintain body temperature, among other things.

“The internal clock is useful only when it is in sync with the external clock, that is the day or night cycle. When a person travels from one time-zone to another, say, from San Diego to Mumbai, as soon as he or she lands in Mumbai, the internal clock is still running on San Diego time and is thus not very useful. As a result, it is realigned to Mumbai time, a process that takes a few days. In the meantime, the person undergoes the well-known adverse effects...namely, jet

http://www.financialexpress.com/news/indian-origin-scientists-discover-gene-related-to-sleep-patterns/1288489